Error: “Failed to initialize connection subsystem” in Cisco AnyConnect Secure Mobility Client in Windows 10

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13 Responses

  1. Suman says:

    Thank you so much, it helped me fix my issue.

  2. Trizillion says:

    Thank you, it fixed my problem as well!

  3. Adriano Mendes says:

    It didn’t worked for me. I receive the error “The VPN driver encountered an error. Please restart your computer or device, then try again.”
    And another message “AnyConnect was not able to establish a connection to the specified secure gateway. Please try connecting again.”

  4. John Straffin says:

    Step 3 above in Solution 2 is wrong, should read “Add a new DWORD Value called GlobalUserOffline and set it to 0 (that’s a zero).”

  5. Victor says:

    Thanks, that worked for me!

  6. Zubair Alexander says:

    @John Straffin, thank you for the correction. You are right. Adding a key will create a new folder. I should have said add a DWORD (32-bit) Value. I have made the correction. I appreciate you taking the time to write to me.

  7. Vinod says:

    Superb!! Thanks a lot. Solution 2 quickly solved the problem.

  8. Thomas says:

    Thank you – solution 1 helped me with a sudden error in Windows 8.1.

  9. Anthony says:

    Worked for me! Thank you so much!

  10. EsstGee says:

    I didn’t do any of these things – I got it to work again by going the the network adapters listing and I noticed the Cisco AnyConnect VPN adapter was disabled (possibly from the Windows Update?). I re-enabled the adapter and it worked after that.

  11. Kimberly says:

    My issue stems from windows 8. This is not useful for my issue. I have the same issue. Getting the “failed to initialize” error.

  12. Ramji says:

    Nice. Worked for me. Thank you.

  13. Steven says:

    Very nice! It’s working for me! Thank you very much.

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